: [Ÿ ̺] ÷ ִ Ÿ A
ŭ ȿɵ پ Ÿ' 츮 󸶳 ˰ ? ̴ ذ(߾Ӿ౹) ̴ Բ ٻ ε Ÿ ̵带 óѴ. ̴ Ÿκ(VITAMIN+BIBLE) Բ Ÿο ڼ ˾ƺ.



ǥ 뼺 Ÿ Ÿ A ÷° ū ִ. Ÿ A (Retina) Ե ̸ Ƽ̵(Retinoid) Ҹ ͸ , ÷° Ÿ A ִ.

Ÿ A ó: Ƽ̹ ũ



Ÿ A

Ÿ A ȱ þ ν ʼ Ѵ. 'ȱ' '߸', 'Ǹ' ִ. ̿ܿ ' п' 'ȭ', ' ' '' 'ߴ' ū Ѵٴ ֱٿ ȭǰ ٽ ε θ ǰ ִ. Ÿ A Ϲ A1 A2, 2 ִ. 츮 Ÿ A θ Ÿ A1̴. A1 ǥ ·δ Ƽ(Retinol) , ȱ ˵̵(Aldehyde) Ƽ(Retinal), īǻ(Carboxylic acid) Ƽͻ(Retinoic acid) ȯȴ. A2 A1 ģȭ ȭչ ηƼ(3-dehydroretinol), ηƼ(3-dehydroretinal), ηƼ(3-dehydroretinoic acid) Ѵ. Ÿ A ü īƼ̵(Cartenoid) Ĺ ǰ Ե ̴. īƼ̵ зDZ ؼ  ̻ -ionone ring ־ Ѵ. īƾ(Carotene) ǥ īƼ̵ âڿ صǾ Ÿ A ȯǴ ־ κŸ A(Pro-Vitamin A) Ҹ. ߿ -īƾ Ƽ 2 ̷ ִ. -īƾ (Intestinal mucosal cell) 2еǾ 2 Ƽ ȯDZ Ÿ A Ȱ ش. Ÿ A Ÿ (IU, International Unit), Ƽ 緮(RE, Retinol Equivalents), Ƽ Ȱ緮(RAE, Retinol Activity Equivalents) ִ. , Ƽ Ÿīƾ ȯ ٸ ǰ ƴ ̰ ִ. Ÿ A 1 뷮 700~800 RE(2,331~2,664 IU)̸, 뷮(UL, Tolerable Upper Intake Level) 3,000RE(10,000 IU) ̺ ϰ Ǹ Ÿ ִ.



ü ŸA

Ÿ A ӿ Ƽ (Retinyl ester) īƼ̵ · Ǿ ִ. ַ Ե Ƽ Ȳ , 뼺 ̴. ´ ڿ÷ Ҿ ¶, Ƽ · Ѵ. ϸ, ȭ ȿ ۿ뿡 Ƽ ƹ̳, صȴ. Ŀ , , ۸̵, ݷ׷Ѱ Բ ̼(Micelle) Ǿ ȴ. ̼ Ƽ ܹ(CRBPII, cellular retinol binding-protein II) ٽ Ƽ-׸ȭ(Retinyl-esterification)ǰ, ܹ ιũ(Chylomicron) Բ ̵Ǿ ݵȴ. ̵ Ƽ-׸ Ƽ صǸ, ص Ƽ CRBPII Բ ǰ Ϻδ ȴ. Ĺ Ÿ A īƾ 迭 (Xanthophylls) ü Ƽ ȯϴµ ̶ īƾ 15,15'-ðԳ(Beta-carotene 15,15'-monooxygenase) ȿҰ ʿϴ. ܹ -īƾ ´ ȿ ۿ뿡 ƹ̳ صǾ -īƾ ȴ. , , ۸̵, ݷ׷Ѱ Բ ̼ ǰ, Ǿ 2 Ƽ ɰ ȴ. Ϻδ CRBPII Ŀ ƾƹ̵ Ƶ ̴ŬŸ̵(NADH) Ƽ-׸ ȯǾ Ƽ ׸ η ϱ⵵ Ѵ. κ Ƽͻ 񰡿 ȯ 弼 ̵ ˺ι(Albumin) ؼ ˺ι-Ƽ ü · ̵ϰ ȴ. Ƽ-׸ صǾ (Parenchymal cell)  , Ƽ Ƽ մܹ(RBP, Retinol-binding proteins) Ͽ ̵ϰų, ٽ 翡׸ȭ(Re-esterification)Ͽ ȴ. κ Ƽ (Stellate cell), Ҽ ٸ 漺е Բ ȴ. Ÿ A 밡 ִ Ѱġ Ÿ A Ƽ-׸ · Ѵ. ׸ Ƽ صǾ, RBP Ͽ CRBP-1 Holo-RBP ϰ ȴ. Holo-RBP RBP κп ƮƼƾ(TTR) ˺ι(Pre-albumin) Ͽ, Ƽ-RBP-TTR ü · ϴٰ ǥ (Target cell) ̵Ѵ. Ƽ ǥ  ǥ鿡 RBP νϴ Ư ü(Receptor) ־ ̿ ۿ ̷ ȴ.



ŸA Ȱ

Ƽ RBP-TTR ü · Ͽ, ⼼(Photoreceptor cell) ̵Ѵ. (Rod cell) ܰ 11-ýƼ(11-cis retinal) յǾ ִ ɽ(Opsin) Ư (lysine) Ѵ. RPSB(Retinal protonated Schiff base) ϸ, ε(Rhodopsin) Ѵ. ɷ ִ , ߱ü ڱϸ εſ ִ 11-cis retinal ̼ü Ʈ Ƽ(All-trans retinal) ȯȴ. ̷ ̼üȭ(Isomerization) ε ڸ ڱؼ Ҿϰ ᱹ ε All-trans retinal ɽ иȴ. 11-cis retinal ܰ ̼ü All-trans retinal ǵư. ο ¿ All-trans retinal 11-cis retinyl ester isomerase ȿҿ ؼ 11-cis retinal ȴ. ε صǰ Ǵ , Ƽ ݾ Ƽλ̳ ٸ Ȱ ȯǾ 輳Ǹ Ҹȴ. ׷⿡ Ƽ ؼ Ҹ ؼ ޵Ǿ Ѵ. All-trans retinol 󵵴 ε ϴ ӵ ϰ, ϴ ӵ Ÿ A 󵵿 ִ. ε ִ Žϱ ߰ ÷¿ ſ ߿ϴ. Ÿ A Ǽ ȭ ߿ Ѵ. Ǽ Ǻ, , 䵵, ȣ ǿ Ѵ. Ǽ ϸ, ̰ кϿ ϴ. Ÿ A ̵Ǹ , ұĢϰ ׷, Ͽ ȭ ° ȴ. ̷ Ǽ ̻ DZ . Ư Ƽͻ Ǽ ϴ ʿϴ. Ƽͻ ̼ (Kerationocyte) ȭ Ͽ Ǽ ǵ ش. CRBP յ All-trans retinol all-trans retinoic acid ȭǸ, ̼ü 9-cis retinol ȯǾٰ 9-cis retinoic acid ȭ ִ. All-trans 9-cis retinoic acid Ƽλմܹ(CRABP, Cellular retinoic acid binding protein) ٸ ܹ ̵Ͽ Ƽͻ (RAR, Retinoic acid receptor) Ǵ Ƽ̵ X ( RXR, Retinoid X receptor) ϳ Ǵ ̻ ⿡ Ѵ. ̷ տ 簡 ۵Ǿ Ѵ. RXR ٸ ȣ ü ׷δ̸(Heterodimer) Ͽ, (Responsible element) ģȭ Ų.



= ̴ ذ (߾Ӿ౹)

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